| Match | Thu | 03/24/2022 | 6:00pm | Aberdeen Central | Parkview Tennis Courts - Rapid City |
| Match | Fri | 03/25/2022 | 9:00am | Rapid City Central | Parkview Tennis Courts - Rapid City |
| Match | Fri | 03/25/2022 | 3:00pm | Rapid City Christian | Sioux Park |
| Match | Sat | 03/26/2022 | 9:00am | Spearfish High School | Sioux Park |
| Match | Sat | 03/26/2022 | 11:30am | Sioux Falls Christian | Parkview Tennis Courts - Rapid City |
| Match | Tue | 04/05/2022 | 4:00pm | Rapid City Christian | Sioux Park |
| Match | Thu | 04/07/2022 | 12:00pm | Sioux Falls Roosevelt | McKennan Park - Sioux Falls |
| Match | Thu | 04/07/2022 | 2:00pm | O'Gorman | McKennan Park - Sioux Falls |
| Match | Fri | 04/08/2022 | 9:00am | Harrisburg | Harrisburg High School |
| Match | Fri | 04/08/2022 | 2:30pm | Mitchell | Mitchell (SD) High School |
| Match | Tue | 04/12/2022 | 4:00pm | Rapid City Central | Parkview Tennis Courts - Rapid City |
| Match | Tue | 04/19/2022 | 4:00pm | Rapid City Christian | Parkview Tennis Courts - Rapid City |
| Match | Thu | 04/21/2022 | 4:00pm | Spearfish High School | Spearfish High School |
| Match | Thu | 04/28/2022 | 4:00pm | Aberdeen Central | Parkview Tennis Courts - Rapid City |
| Tournament | Fri | 04/29/2022 | TBD | Rapid City | Sioux Park |
| Tournament | Sat | 04/30/2022 | TBD | Rapid City | Sioux Park |
| Match | Tue | 05/03/2022 | 4:00pm | Rapid City Central | Parkview Tennis Courts - Rapid City |
| Tournament | Thu | 05/05/2022 | 1:00pm | Lennox | Pierre High School |
| Tournament | Thu | 05/05/2022 | 3:30pm | Watertown (SD) | Pierre High School |
| Tournament | Thu | 05/05/2022 | 5:30pm | Pierre T.F. Riggs | Pierre High School |
| Tournament | Fri | 05/06/2022 | 8:00am | Sioux Falls Christian | Pierre High School |
| Match | Tue | 05/10/2022 | 6:30pm | Rapid City Stevens | Sioux Park |
| Match | Fri | 05/13/2022 | 1:00pm | Sioux Falls Washington | Sioux Falls |
| Match | Fri | 05/13/2022 | 4:00pm | Sioux Falls Lincoln | Sioux Falls |
| Match | Sat | 05/14/2022 | 8:00am | Sioux Falls Roosevelt | Sioux Falls |
| Match | Sat | 05/14/2022 | 11:00am | O'Gorman | Sioux Falls |
| State | Mon | 05/16/2022 | TBD | Rapid City | Sioux Park |
| State | Tue | 05/17/2022 | TBD | Rapid City | Sioux Park |
